Mechanical confinement induces ferroptosis through mitochondrial dysfunction
Fang Zhou, Robert J. Ju, Chenlu Kang, Jiayi Li, Ao Yang, A. Libert, Yujie Sun, Ling Liang, Youwei Ai, Xiaoqing Hu, Samantha J. Stehbens, Congying Wu
This study shows that mechanical confinement triggers ferroptosis via mitochondrial dysfunction by inducing Drp1-dependent fragmentation and cPLA2 translocation.
Nature Communications · Nov 28, 2025Peer-reviewedCell Biology