Author

Youwei Ai

Chinese Academy of SciencesORCID 0000-0002-2698-623XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

A. LibertiD· 1 shared Ao YangiD· 1 shared Chenlu Kang· 1 shared Congying WuiD· 1 shared Fang Zhou· 1 shared Guanghou ShuiiD· 1 shared Haiwen Lin· 1 shared Haotian Wang· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperCell Biology

A. LibertORCID

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3 papers

Recent·Most cited

mTORC1 Directs TNF-Induced Life-or-Death Decisions via Complex I Destabilization

Zhao Deng, Jingyi Wang, Zhao Deng, Kai Yu, Yan Liu, Kai Yu, Haiwen Lin, Jiafan Yuan, Tingyun Yang, Haotian Wang, T T Yang, Youwei Ai

This paper shows mTORC1 regulates TNF-induced cell death by destabilizing complex I and promoting complex II formation, with implications for disease therapies.

bioRxiv · Jun 29, 2026 · PreprintCell Biology

Mechanical confinement induces ferroptosis through mitochondrial dysfunction

Fang Zhou, Robert J. Ju, Chenlu Kang, Jiayi Li, Ao Yang, A. Libert, Yujie Sun, Ling Liang, Youwei Ai, Xiaoqing Hu, Samantha J. Stehbens, Congying Wu

This study shows that mechanical confinement triggers ferroptosis via mitochondrial dysfunction by inducing Drp1-dependent fragmentation and cPLA2 translocation.

Nature Communications · Nov 28, 2025Peer-reviewedCell Biology

Spatial organization of PI3K-PI(3,4,5)P3-AKT signaling by focal adhesions

Jing Wang, Zhengyang An, Zhongsheng Wu, Wei Zhou, Pengyu Sun, Piyu Wu, Song Dang, Rui Xue, Xue Bai, Yongtao Du, Rongmei Chen, Wenxu Wang, Pei Huang, Sin Man Lam, Youwei Ai, , Kangmin He

This study identifies focal adhesions as the subcellular hubs organizing PI3K-PI(3,4,5)P3-AKT signaling, showing localized lipid production and AKT activation, and demonstrates that combined inhibition of PI3K and FAK enhances cancer cell suppression.

Molecular Cell · Nov 1, 2024Peer-reviewedCell Biology