Robert J. Ju

The way less obvious: PIEZO1 supports apoptotic cell extrusion by optimizing tissue mechanical tension for homeostasis.

This study shows PIEZO1 supports apoptotic cell extrusion by maintaining mechanical homeostasis rather than through calcium signaling.

Mechanical confinement induces ferroptosis through mitochondrial dysfunction

This study shows that mechanical confinement triggers ferroptosis via mitochondrial dysfunction by inducing Drp1-dependent fragmentation and cPLA2 translocation.

Tuning non-linear mechanics in collagen hydrogels modulates three dimensional cellular morphotypes

This study shows that altering the non-linear elasticity of collagen hydrogels affects cell morphology, migration, and matrix deformation through mechanical interactions with a second polymer component.

Genomic analysis of patient-derived xenograft models reveals intra-tumor heterogeneity in endometrial cancer and can predict tumor growth inhibition with talazoparib

The paper develops endometrial cancer PDX models that capture tumor heterogeneity and predict response to talazoparib.