Ling Liang

ADP-ribose triggers neuronal ferroptosis by rewiring purine and pyrimidine metabolism

This study identifies ADP-ribose as a mediator of neuronal ferroptosis through metabolic rewiring, showing that blocking its signaling alleviates cognitive decline in mouse models.

Structural insights into cholesterol sensing by the LYCHOS-mTORC1 pathway

This study reveals the structural mechanism of cholesterol sensing by LYCHOS, showing how cholesterol binding modulates its interaction with GATOR1 to activate mTORC1.

Blebs regulate phosphoinositides distribution and promote cell survival through the Septin-SH3KBP1-PI3K axis

The paper shows blebs regulate phosphoinositides distribution via the Septin-SH3KBP1-PI3K axis, promoting cell survival during anoikis resistance.

Synergistic activation of the human phosphate exporter XPR1 by KIDINS220 and inositol pyrophosphate

This study reveals how XPR1, a phosphate exporter, is regulated by KIDINS220 and inositol pyrophosphate through structural and functional analyses.

A conserved N-terminal motif of CUL3 mediates assembly and licenses E3 ligase activation of CRL3KLHL22

The paper identifies a conserved N-terminal motif in CUL3 that mediates dimerization and activates CRL3KLHL22 E3 ligase function.