Cancer-associated adipocytes mediate CD8+T cell dysfunction via FGF21-driven lipolysis
Sumiya Dalangood, Cegui Hu, Chenwei Yuan, Xiang Olivia Li, Wen Qiao, Hanjun Li, Rongyu Zhang, Luying Li, Li Peng, Xiang Yu, Wenjin Yin, Jinsong Lu, Jun Gui
This study identifies FGF21-driven lipolysis in cancer-associated adipocytes as a mechanism causing CD8+T cell dysfunction, showing that targeting this process can enhance cancer immunotherapy.
Cell Reports · Nov 1, 2025Peer-reviewedCancer Biology