Xiang Yu

miRstring: An RNA language model enables mature miRNA decoding and artificial small RNA design across species

miRstring decodes mature miRNA boundaries from precursor context across species and designs artificial miRNAs effectively.

Cancer-associated adipocytes mediate CD8+T cell dysfunction via FGF21-driven lipolysis

This study identifies FGF21-driven lipolysis in cancer-associated adipocytes as a mechanism causing CD8+T cell dysfunction, showing that targeting this process can enhance cancer immunotherapy.

Arabidopsis DXO1 is an evolutionarily diverged homolog that impacts ribosome loading and mRNA surveillance

This study identifies Arabidopsis DXO1 as a diverged ortholog involved in 5'-end RNA quality control, ribosome loading, and mRNA surveillance through its serine-rich N-terminal domain.

Post-transcriptional Regulation Coordinating Transcription and Translation During Circadian Oscillation and Stress Recovery in Plants

The paper identifies post-transcriptional mechanisms coordinating transcription and translation rhythms in Arabidopsis under circadian and stress conditions.

SLE non-coding Genetic Risk Variant Determines the Epigenetic Dysfunction of an Immune Cell Specific Enhancer that Controls Disease-critical microRNA Expression

The paper identifies a non-coding genetic variant associated with SLE that regulates miR-146a expression through a cell-type specific enhancer.