Eileen M. Crimmins

This study finds that exposure to the 2004 Indian Ocean tsunami led to long-term reductions in free triiodothyronine levels and increased cardiometabolic risk 20 years later.

This study investigates how actin structure and function affect aging in C. elegans and finds that actin dysfunction accelerates aging hallmarks and correlates with human age-related decline in gait speed.

The paper identifies mitochondrial SNPs interacting with Klotho variants to influence diabetes risk, showing sex-dependent effects using the NuMIT method.

The paper develops 11 system-specific methylation clocks from blood samples to quantify aging heterogeneity across physiological systems and identifies aging subtypes with distinct disease patterns.

The paper develops mortality-based predictors of biological age for 9 physiological systems using blood data from the UK Biobank and validates them in the Health and Retirement Study.

The paper trains a computational model to deconvolve fifteen leukocyte subtypes from DNA methylation data using flow cytometry data, improving variance explanation and reducing false positives in age studies.

This paper introduces a computational method to improve the reliability of epigenetic clocks by using principal component analysis, showing reduced technical noise and better performance in longitudinal studies.

The paper identifies ALDH4A1 genetic variation as a biomarker for age-related muscle health across species using C. elegans and human data.