Sara Hägg

Genome-Wide Association Study of Distressing Premenstrual Symptoms in Two Nordic Populations

This paper conducts a GWAS of distressing premenstrual symptoms (DPS) in two Nordic populations, identifying a SNP associated with DPS and genetic correlations to psychiatric disorders.

Genomic analyses reveal new insights into Alzheimer's disease

This study identifies 118 new genetic loci associated with Alzheimer's disease across diverse ancestries and discovers 48 novel risk loci, including those enriched in neuronal cell types.

Systems Age: A single blood methylation test to quantify aging heterogeneity across 11 physiological systems

The paper develops 11 system-specific methylation clocks from blood samples to quantify aging heterogeneity across physiological systems and identifies aging subtypes with distinct disease patterns.

Heritability of human lifespan is about 50% when confounding factors are addressed

This paper estimates that the heritability of human lifespan is about 50% when accounting for extrinsic factors and cutoff age effects, challenging the consensus that genetics has a minor role in lifespan.

Biological aging of different blood cell types

The paper compares biological age indicators across different blood cell types and finds cell type-specific associations with calendar age.

Genome-wide meta-analyses of non-response to antidepressants identify novel loci and potential drugs

This study identifies two novel genomic loci associated with antidepressant non-response and suggests potential drugs for further validation.

A computational solution for bolstering reliability of epigenetic clocks: Implications for clinical trials and longitudinal tracking

This paper introduces a computational method to improve the reliability of epigenetic clocks by using principal component analysis, showing reduced technical noise and better performance in longitudinal studies.

Methylation status of VTRNA2-1/nc886 is stable across human populations, monozygotic twin pairs and in majority of somatic tissues

The paper examines nc886 methylation across populations and tissues, finding stable levels except in specific tissues and some discordance in dizygotic twins.

A Genome-Wide Association Study of the Frailty Index Highlights Synaptic Pathways in Aging

This study performs a genome-wide association study of frailty index to identify genetic signals and pathways, finding synapse function enrichment and associations with educational attainment.

Within-sibship GWAS improve estimates of direct genetic effects

In 159,701 siblings from 17 cohorts, population GWAS overstate direct effects on height, education, smoking, cognition, depressive symptoms and age at first birth; clinical traits mostly agree across models.

Deciphering the genetic and epidemiological landscape of mitochondrial DNA abundance

This study estimates mitochondrial DNA abundance in 295,150 UK Biobank participants and identifies genetic and lifestyle factors associated with it, finding links to immune aging, disease risk, and mortality.

A decade of epigenetic change in aging twins: genetic and environmental contributions to longitudinal DNA methylation

This study examines genetic and environmental influences on DNA methylation changes in aging twins over 10 years, finding genetic contributions to stability and environmental factors to novel methylation differences.

DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan

This paper identifies DNA methylation sites associated with aggression through a meta-analysis of epigenome-wide studies across different age groups and tissues.

Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

This study identifies 137 genome-wide significant loci associated with DNA methylation biomarkers of ageing using DNAm and SNP data from over 41,000 individuals.

DNA methylation outlier burden, health and ageing in Generation Scotland and the Lothian Birth Cohorts of 1921 and 1936.

This study examines DNA methylation outlier burden as a marker of biological age and finds it increases with age but is not strongly linked to health outcomes or survival.

Comprehensive longitudinal study of epigenetic mutations in aging

This study examines the accumulation of epigenetic mutations with age using longitudinal blood samples and identifies factors influencing their occurrence.

Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins

This study identifies age-related DNA methylation changes in old Swedish twins over 20 years, showing stability across cohorts and genetic influences independent of age.

GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

This study identifies 206 new genomic loci and 1,041 genes associated with intelligence using a large GWAS meta-analysis of 279,930 individuals.

Genetic meta-analysis identifies 9 novel loci and functional pathways for Alzheimers disease risk

This study identifies 9 novel genetic loci and 215 potential causative genes associated with Alzheimer's disease risk through a large genome-wide association analysis.

An epigenome-wide association study of educational attainment (n = 10,767)

This study investigates the association between CpG methylation and educational attainment, finding limited significant associations that may be influenced by confounding factors.

Large-scale non-targeted metabolomic profiling in three human population-based studies

The paper develops a workflow for large-scale non-targeted metabolomic profiling in human studies, detecting over 8,000 metabolic features and identifying 90 metabolites associated with hsCRP.