Nancy A. Speck

The paper identifies pre-hematopoietic stem cells and their niche using spatial transcriptomics in the AGM region, revealing spatial signaling patterns and cellular interactions that support HSC development.

The paper shows that human-length telomeres in mice restrict hematopoietic stem cell regenerative potential under stress conditions.

This study shows that SMAD7 restrains TGFβ and BMP signaling to enable pre-HSC maturation into HSCs during embryonic hematopoiesis.

This study identifies E2f as a regulator that coordinates cell cycle activity and cell fate decisions in hematopoietic progenitors to drive stress myelopoiesis.

This study shows that RUNX1 in granulocyte-monocyte progenitors limits neutrophil inflammatory cytokine production by restricting retrotransposon chromatin accessibility and type I interferon signaling.

The paper shows that MyD88-dependent TLR signaling in endothelial cells reduces hematopoietic stem cells (HSCs) while increasing committed progenitors and intra-arterial hematopoietic cluster cells by promoting their proliferation.

This study shows that RUNX1 haploinsufficiency reduces megakaryocyte-biased hematopoietic progenitor cells and identifies drug targets to correct this defect.

The paper identifies a pre-hematopoietic (pre-HE) stage in mouse embryos and shows RUNX1 regulates the transition to hemogenic endothelium, leading to distinct HSPC populations in intra-arterial clusters.

The paper examines 3D genome organization, epigenome, and transcriptome changes in fetal and adult mouse HSCs, finding stage-specific chromatin interactions and transcription factor roles.

The paper defines the transcriptomes and epigenomes of key developmental stages of HSC ontogeny in mice and constructs transcriptional regulatory networks using computational methods.