Joanna M. Tober

The paper shows that human-length telomeres in mice restrict hematopoietic stem cell regenerative potential under stress conditions.

This study shows that SMAD7 restrains TGFβ and BMP signaling to enable pre-HSC maturation into HSCs during embryonic hematopoiesis.

This study identifies E2f as a regulator that coordinates cell cycle activity and cell fate decisions in hematopoietic progenitors to drive stress myelopoiesis.

The paper identifies a pre-hematopoietic (pre-HE) stage in mouse embryos and shows RUNX1 regulates the transition to hemogenic endothelium, leading to distinct HSPC populations in intra-arterial clusters.

The paper examines 3D genome organization, epigenome, and transcriptome changes in fetal and adult mouse HSCs, finding stage-specific chromatin interactions and transcription factor roles.

The paper defines the transcriptomes and epigenomes of key developmental stages of HSC ontogeny in mice and constructs transcriptional regulatory networks using computational methods.