Author

Laura F. Bennett

University of PennsylvaniaORCID 0000-0002-4046-0736Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Nancy A. SpeckiD· 4 shared Joanna M. ToberiD· 2 shared Melanie D. MumauiD· 2 shared Wenbao YuiD· 2 shared Yan LiiD· 2 shared Allison R. ScottiD· 1 shared Amanda E Kroesen· 1 shared Anoja G. PereraiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersDevelopmental Biology

Nancy A. SpeckORCID

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4 papers

Recent·Most cited

In situ identification of pre-hematopoietic stem cells and their niche

Xinjian Mao, Ning Zhang, Laura F. Bennett, Xi He, Allison R. Scott, Kate Hall, Kaitlyn Petentler, Seth Malloy, Shengping Huang, Amanda E Kroesen, Sean McKinney, Athanasios Ploumakis, Zhe Yang, Ruochen Dong, Jose Emmanuel Javier, , Linheng Li

The paper identifies pre-hematopoietic stem cells and their niche using spatial transcriptomics in the AGM region, revealing spatial signaling patterns and cellular interactions that support HSC development.

bioRxiv · Oct 6, 2026 · PreprintDevelopmental Biology

Restraint of TGFβ family signaling by SMAD7 is necessary for hematopoietic stem cell maturation in the embryo.

Laura F. Bennett, Wenbao Yu, Chia-Hui Chen, Hyun Hyung An, Joanna M. Tober, Kai Tan, Nancy A. Speck

This study shows that SMAD7 restrains TGFβ and BMP signaling to enable pre-HSC maturation into HSCs during embryonic hematopoiesis.

bioRxiv · Aug 23, 2025 · PreprintDevelopmental Biology

MyD88-dependent TLR signaling oppositely regulates hematopoietic progenitor and stem cell formation in the embryo

Laura F. Bennett, Melanie D. Mumau, Yan Li, Nancy A. Speck

The paper shows that MyD88-dependent TLR signaling in endothelial cells reduces hematopoietic stem cells (HSCs) while increasing committed progenitors and intra-arterial hematopoietic cluster cells by promoting their proliferation.

Development · Jan 19, 2022Peer-reviewedDevelopmental Biology

Developmental trajectory of pre-hematopoietic stem cell formation fromendothelium

Qin Zhu, Peng Gao, Joanna M. Tober, Laura F. Bennett, Changya Chen, Yasin Uzun, Yan Li, Elizabeth D. Howell, Melanie D. Mumau, Wenbao Yu, Bing He, Nancy A. Speck, Kai Tan

The paper identifies a pre-hematopoietic (pre-HE) stage in mouse embryos and shows RUNX1 regulates the transition to hemogenic endothelium, leading to distinct HSPC populations in intra-arterial clusters.

Blood · May 12, 2020Peer-reviewedDevelopmental Biology