Author

Chiara B.E. Marley

Gladstone Institutes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 2

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2

Frequent Co-Authors

Bruce R. ConkliniD· 2 shared Carissa M. Feliciano· 2 shared Hannah L. Watry· 2 shared Luke M. JudgeiD· 2 shared Abin AbrahamiD· 1 shared Angela Z. Liu· 1 shared Bazilco M.J. Simon· 1 shared Dylan Steury· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersGenetics

Bruce R. ConklinORCID

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2 papers

Recent·Most cited

Haplotype editing with CRISPR/Cas9 as a therapeutic approach for dominant-negative missense mutations in NEFL

Poorvi H. Dua, Bazilco M.J. Simon, Chiara B.E. Marley, Carissa M. Feliciano, Hannah L. Watry, Quinn T. Cowan, Dylan Steury, Abin Abraham, Erin N. Gilbertson, Grace D. Ramey, John A. Capra, Bruce R. Conklin, Luke M. Judge

This paper demonstrates haplotype editing with CRISPR/Cas9 to target NEFL missense mutations in iPSC-derived motor neurons, showing therapeutic potential and challenges in disrupting mutant allele expression.

Molecular Therapy · Nov 20, 2025Peer-reviewedGenetics

Allele-specific gene editing rescues pathology in a human model of Charcot-Marie-Tooth disease type 2E

Carissa M. Feliciano, Kenneth Kun-yu Wu, Hannah L. Watry, Chiara B.E. Marley, Gokul N. Ramadoss, Hana Y. Ghanim, Angela Z. Liu, Lyandysha V. Zholudeva, Todd C. McDevitt, Mario Saporta, Bruce R. Conklin, Luke M. Judge

This paper demonstrates allele-specific CRISPR gene editing in a human CMT2E model rescues disease pathology by inactivating the mutant NEFL allele.

Frontiers in Cell and Developmental Biology · Aug 16, 2021Peer-reviewedGenetics