Todd C. McDevitt

Distinct differentiation trajectories leave lasting impacts on gene regulation and function of V2a interneurons

The paper shows that lineage origins shape gene regulation and function in V2a neurons, identifying key regulators specific to posterior identities.

CDX2 dose-dependently influences the gene regulatory network underlying human extraembryonic mesoderm development

This study shows CDX2 dose-dependently regulates genes involved in tissue permeability, cell-cell adhesion, and cytoskeletal structure during extraembryonic mesoderm development using human induced pluripotent stem cells.

TBXT dose sensitivity and the decoupling of nascent mesoderm specification from EMT progression in 2D human gastruloids

This study shows that TBXT dose affects the timing of EMT in human gastruloids without compromising mesoderm differentiation.

Human spinal interneurons repair the injured spinal cord through synaptic integration

This study shows that human cervical V2a interneurons transplanted into injured spinal cords form functional synaptic connections with host tissue, improving diaphragm activity.

Allele-specific gene editing rescues pathology in a human model of Charcot-Marie-Tooth disease type 2E

This paper demonstrates allele-specific CRISPR gene editing in a human CMT2E model rescues disease pathology by inactivating the mutant NEFL allele.

Passive clearing and 3D lightsheet imaging of the intact and injured spinal cord in mice

This paper optimizes the PACT clearing technique for 3D imaging of intact and injured mouse spinal cords to study neural circuits and SCI-related changes.

Axial Elongation of Caudalized Human Organoids Mimics Neural Tube Development

This study uses caudalized human pluripotent stem cell organoids to model neural tube axial elongation, showing gene expression patterns and morphological features similar to development.

Silencing of E-cadherin in induced human pluripotent stem cells promotes extraembryonic fates accompanying multilineage differentiation

This study shows that reducing E-cadherin in 3D encapsulated human pluripotent stem cells leads to extraembryonic fates and multilineage differentiation, mimicking early embryonic development.

Developmental co-emergence of cardiac and gut tissues modeled by human iPSC-derived organoids

This study shows that human iPSC-derived organoids can model the cooperative development of cardiac and gut tissues through paracrine signaling.