Author

Hana Y. Ghanim

Stanford MedicineORCID 0000-0002-4102-2367Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 2 Genetics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:drug response / drug discovery· 3 Assay:CRISPR screen· 2 Approach:experimental assay· 2 Approach:genetic perturbation / CRISPR· 2 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Amanda M. DudekiD· 2 shared Kaya Ben-Efraim· 2 shared Matthew Hebden PorteusiD· 2 shared Nicole M. Johnston· 2 shared Sofia E. LunaiD· 2 shared William N. FeistiD· 2 shared A.R. Friedman· 1 shared Adiel Charbash· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBioengineering

Amanda M. DudekORCID

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Author profile →

4 papers

Recent·Most cited

Engineering hematopoietic stem and progenitor cells to generate red blood cells as viral traps against HIV-1

Sofia E. Luna, William N. Feist, Kaya Ben-Efraim, Michael A. Pendergast, Freja K. Ekman, Britney N. Hernandez, Megan E. Merritt-Garza, Kathleen Romero, Zak Kostamo, Nelson A. Amorin, Nicole M. Johnston, Hana Y. Ghanim, Vivien Sheehan, Amanda M. Dudek, Matthew Hebden Porteus

This paper engineers hematopoietic stem and progenitor cells to express CD4 on red blood cells, creating viral traps to neutralize HIV-1.

Molecular Therapy Advances · Sep 10, 2026Peer-reviewedBioengineering

Combining Cell-Intrinsic and -Extrinsic Resistance to HIV-1 By Engineering Hematopoietic Stem Cells for CCR5 Knockout and B Cell Secretion of Therapeutic Antibodies

William N. Feist, Sofia E. Luna, Kaya Ben-Efraim, Maria V. Filsinger Interrante, Alvaro Amorin, Nicole M. Johnston, Theodora U. J. Bruun, Ashley Utz, Hana Y. Ghanim, Benjamin J. Lesch, Theresa M. McLaughlin, Amanda M. Dudek, Matthew Hebden Porteus

This paper describes engineering hematopoietic stem cells to produce CCR5 knockout cells and secrete HIV-1 inhibiting antibodies, aiming for a one-time cure for HIV-1.

Nature Communications · Mar 31, 2025Peer-reviewedBioengineering

Allele-specific gene editing rescues pathology in a human model of Charcot-Marie-Tooth disease type 2E

Carissa M. Feliciano, Kenneth Kun-yu Wu, Hannah L. Watry, Chiara B.E. Marley, Gokul N. Ramadoss, Hana Y. Ghanim, Angela Z. Liu, Lyandysha V. Zholudeva, Todd C. McDevitt, Mario Saporta, Bruce R. Conklin, Luke M. Judge

This paper demonstrates allele-specific CRISPR gene editing in a human CMT2E model rescues disease pathology by inactivating the mutant NEFL allele.

Frontiers in Cell and Developmental Biology · Aug 16, 2021Peer-reviewedGenetics

Blood-brain barrier dysfunction in aging induces hyper-activation of TGF-beta signaling and chronic yet reversible neural dysfunction

Vladimir V. Senatorov, A.R. Friedman, Dan Z. Milikovsky, Jonathan Ofer, Rotem Saar‐Ashkenazy, Adiel Charbash, Naznin Jahan, G. Chin, Eszter Mihaly, Jessica May Lin, Harrison J. Ramsay, Ariana Neelufar Moghbel, Marcela K. Preininger, Chelsy R. Eddings, Harland V. Harrison, , Daniela Kaufer

This study shows BBB dysfunction in aging leads to TGF-beta hyperactivation in astrocytes, causing neural dysfunction, which can be reversed by inhibiting TGF-beta signaling.

bioRxiv · Feb 1, 2019 · PreprintNeuroscience