Epigenetic change induced by in utero dietary challenge provokes phenotypic variability across multiple generations of mice
Mathew Van de Pette, António Miguel Galvão, Steven J. Millership, Wilson To, Andrew Dimond, Chiara Prodani, Gráinne I. McNamara, Ludovica Bruno, Alessandro Sardini, Zoë Webster, James McGinty, P. M. W. French, Anthony G. Uren, Juan Castillo Fernandez, Rosalind M. John, , Amanda G. Fisher
The paper shows that maternal high-fat diet induces epigenetic changes in mice that affect two generations, with altered Dlk1 expression and DNA methylation.
bioRxiv · Aug 7, 2020 · PreprintDevelopmental Biology