Andrew Dimond

Individual mouse mitotic chromosomes exhibit cell type-specific differences in biomechanical properties

The paper shows that mouse metaphase chromosomes from different cell types have distinct biomechanical properties, with ESC-derived chromosomes showing conserved force-dependent responses but differing from those of NSCs and preB cells.

PBK/TOPK mediates Ikaros, Aiolos and CTCF displacement from mitotic chromosomes and alters chromatin accessibility at selected C2H2-zinc finger protein binding sites

The paper shows PBK/TOPK phosphorylates Ikaros, Aiolos, and CTCF to displace them from mitotic chromosomes, altering chromatin accessibility at specific zinc finger protein sites.

Loss of H3K9 tri-methylation alters chromosome compaction and transcription factor retention during mitosis

The paper shows that loss of H3K9 tri-methylation leads to smaller, more compact mitotic chromosomes and altered transcription factor retention.

Epigenetic change induced by in utero dietary challenge provokes phenotypic variability across multiple generations of mice

The paper shows that maternal high-fat diet induces epigenetic changes in mice that affect two generations, with altered Dlk1 expression and DNA methylation.