Gavin Kelsey

Epigenomic profiling of cerebrospinal fluid cells identifies immune regulatory alterations and implicates protocadherins in multiple sclerosis

This study identifies DNA methylation changes in cerebrospinal fluid cells from MS patients, linking them to immune regulatory alterations and implicating protocadherins in MS pathogenesis.

An Nlrp5-null mutation leads to attenuated de novo methylation in oocytes, accompanied by a significant reduction in DNMT3L

This study shows that Nlrp5-null oocytes have reduced DNMT3L and impaired de novo methylation, leading to imprinting disorders and developmental issues.

A maternal-effect Padi6 variant results in abnormal nuclear localization of DNMT1 and failure of epigenetic reprogramming and zygotic genome activation in mouse embryos

Multi-omics analysis demonstrates a critical role for GLP methyltransferase in transcriptional repression during oogenesis

The paper investigates the role of GLP methyltransferase in oocyte development using multi-omics analysis and mouse models, finding that GLP contributes to transcriptional repression and is critical for oogenesis.

Loss of histone methyltransferase SETD1B in oogenesis results in the redistribution of genomic histone 3 lysine 4 trimethylation

This study shows that loss of SETD1B in oocytes causes redistribution of H3K4me3, with loss at active promoters and gain at CpG-rich regions, revealing distinct roles for SETD1B and MLL2 in epigenetic regulation.

Epigenetic change induced by in utero dietary challenge provokes phenotypic variability across multiple generations of mice

The paper shows that maternal high-fat diet induces epigenetic changes in mice that affect two generations, with altered Dlk1 expression and DNA methylation.

Single cell multi-omics profiling reveals a hierarchical epigenetic landscape during mammalian germ layer specification

The paper uses single cell triple-omics analysis to reveal how epigenetic changes drive germ layer specification in mouse embryos, showing distinct epigenetic priming and remodeling in different lineages.

Genome-scale oscillations in DNA methylation during exit from pluripotency

The paper shows that during exit from pluripotency, coexpression of DNMT3s and TETs drives genome-scale DNA methylation oscillations, with amplitude dependent on CpG density, observed both in vitro and in vivo.

scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells

This paper introduces scNMT-seq, a method for joint profiling of chromatin accessibility, DNA methylation, and transcription in single cells, and validates it in differentiating mouse embryonic stem cells.