A Non-Canonical Interface of SNX9 PX Domain Selectively Sequesters PI(3,4)P2 Lipids, Protecting Them from Hydrolysis
Jeriann R. Beiter, Chieh-Ju Sung, Shan‐Shan Lin, Nicolas DeVuono, Senthil Arumugam, John Manzi, Aurélie Bertin, Patricia M. Bassereau, Ya-Wen Liu, Gregory A. Voth, Feng‐Ching Tsai
This study shows SNX9 selectively binds PI(3,4)P2 lipids through a non-canonical interface, protecting them from hydrolysis during membrane remodeling.
bioRxiv · Mar 26, 2025 · PreprintBiophysics