Aurélie Bertin

Septin Architecture Dictates Size-Dependent Diffusion Barriers on biomimetic Membranes

This study shows septins create size-dependent diffusion barriers on synthetic membranes by organizing into filaments, restricting the movement of membrane-bound objects with large cytosolic domains.

Reconstruction of septin higher-order nano-size structures in ovarian cancer cells uncover susceptibility to the septin-targeting small molecule UR214-9

This paper demonstrates that UR214-9 disrupts septin hetero-octamerization, leading to aberrant structures and impairing cancer cell functions.

Unexpected softening of giant unilamellar vesicles by budding yeast septin filaments: a curvature dependent mechanism

The paper investigates how budding yeast septin filaments affect the mechanical properties of giant unilamellar vesicles (GUVs), finding that large GUVs become more deformable while small ones become less deformable due to septin-induced membrane reshaping.

Diffusion Probabilistic Models for Missing-Wedge Correction in Cryo-Electron Tomography

The paper introduces MW-RaMViD, a diffusion model for correcting missing-wedge artifacts in cryo-ET by generating missing tilt images, showing improved reconstruction fidelity with smaller step sizes and larger conditioning windows.

Architecture and function of Bud3 and Bud4-induced septin structures

This study investigates the role of Bud3 and Bud4 in organizing septin structures during cytokinesis in budding yeast, showing they form distinct filaments and cooperate to create higher-order networks.

A Non-Canonical Interface of SNX9 PX Domain Selectively Sequesters PI(3,4)P2 Lipids, Protecting Them from Hydrolysis

This study shows SNX9 selectively binds PI(3,4)P2 lipids through a non-canonical interface, protecting them from hydrolysis during membrane remodeling.

Guanidine hydrochloride reactivates an ancient septin hetero-oligomer assembly pathway in budding yeast

The paper shows that guanidine hydrochloride reactivates an ancient septin hexamer assembly pathway in yeast by mimicking a missing arginine sidechain in Cdc3.