Histone H3 Lysine 4 methyltransferases MLL3 and MLL4 Modulate Long-range Chromatin Interactions at Enhancers
Jian Yan, Shi-An A. Chen, Andrea Local, Tristin Liu, Yunjiang Qiu, Ah Young Lee, Inkyung Jung, Sebastian Preißl, Chloe M. Rivera, Chaochen Wang, Haruhiko Ishii, Rongxin Fang, Zhen Ye, Kai Ge, Ming Hu, Bing Ren
This study shows that MLL3/4 proteins regulate chromatin interactions at enhancers by depositing H3K4me1, which recruits Cohesin to facilitate chromatin looping.
bioRxiv · Feb 21, 2017 · PreprintGenomics