Inkyung Jung

This study shows that the Acvr1R206H mutation in FOP remodels chromatin through BMP-SMAD and Rho/ROCK signaling, driving aberrant osteogenesis, and identifies reversible chromatin changes as a therapeutic target.

This study identifies chromatin stability as critical for preserving chondrocyte function during expansion and shows that Fludarabine maintains phenotype by stabilizing chromatin and reducing STAT1 activity.

This study identifies age-dependent chromatin remodeling in tendon cells that enhances inflammatory responses and contributes to tendon degeneration.

This study shows that the EZH1Q571R mutation enhances chromatin compaction and PRC2 activity, leading to repression of tumor suppressor genes in follicular thyroid cancer.

The paper investigates the role of EZH2 in Duchenne muscular dystrophy and shows that inhibiting EZH2 improves muscle phenotype in Dmd mutant mice when combined with glucocorticoids.

GEM-Finder identifies disease-associated CREs by integrating transcriptomic, epigenomic, and chromatin interaction data during endothelial differentiation, revealing 7.6 times more associations than conventional methods.

This study identifies cell-type-specific dysregulated cis-regulatory elements and target genes in Parkinson's disease using multi-omic analyses of single-cell transcriptomes and epigenomes.

This study shows that CHD4 regulates chromatin accessibility to hide aberrant CTCF-binding sites within TADs in mESCs, preventing TAD disorganization.

The paper identifies a new class of super-enhancers active across multiple cell/tissue types and links them to fast-recovering 3D chromatin loops.

The paper analyzes genetic diversity across 11,257 human genomes to identify context-dependent conserved regions and their association with disease variants.

This study shows that MLL3/4 proteins regulate chromatin interactions at enhancers by depositing H3K4me1, which recruits Cohesin to facilitate chromatin looping.