Chaochen Wang

scSAID provides a cross-species single-cell skin atlas to study psoriasis, revealing species-specific molecular signatures and identifying a novel drug target.

scCDC detects and corrects contamination in scRNA-seq and snRNA-seq data by identifying contamination-causing genes, achieving better accuracy than existing methods.

The paper develops a webtool to predict CRISPRa/i efficacy using epigenetic features from single-cell RNA-Seq and K562 cell data, validated by CROP-Seq assays.

HiCArch predicts high-resolution Hi-C contact matrices from 1D epigenomic features, achieving high correlation scores and identifying TADs with 10kb resolution.

This study shows that H3.3K4M destabilizes MLL3/4 proteins, preventing enhancer activation and impairing adipose tissue development.

The paper investigates eRNA levels in a mammary super-enhancer and finds they do not correlate with individual enhancer activity but predict super-enhancer activity when elements are removed.

This study shows that MLL3/4 proteins regulate chromatin interactions at enhancers by depositing H3K4me1, which recruits Cohesin to facilitate chromatin looping.