Mechanism of Gating and Isoform-Specific Inhibition in Renal CLC Chloride Channels
Chih-Ta Chien, Briana L. Sobecks, Alexander S. Powers, Anindita Das, Jürgen Kreiter, Chloe N. Barry, Muyuan Chen, Andrew Hinman, Camille Fisher Petrakian, Natasa Trifkovic, Brianna B. Williams, Chase A. P. Wood, Mengyuan Xu, Ron O. Dror, Wah Chiu, Merritt C. Maduke
The paper investigates how BIM1 selectively inhibits CLC-Ka over CLC-Kb by analyzing cryo-EM structures and showing that interactions with a conserved lysine and dynamic gating-loop behavior underlie this selectivity.
Proceedings of the National Academy of Sciences · Sep 1, 2026Peer-reviewedBiophysics