Author

Briana L. Sobecks

Stanford MedicineORCID 0000-0003-2086-8598Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 2 Assay:cryo-EM· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Ron O. DroriD· 3 shared Chih-Ta ChieniD· 2 shared Jürgen KreiteriD· 2 shared Merritt C. MadukeiD· 2 shared Wah ChiuiD· 2 shared Alexander S. PowersiD· 1 shared Amy R. NavaiD· 1 shared Andrew C. KruseiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersBiophysics

Ron O. DrorORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

BiophysicsProceedings of the National Academy of SciencesPeer-reviewedSep 1, 2026

Mechanism of Gating and Isoform-Specific Inhibition in Renal CLC Chloride Channels

Chih-Ta Chien, Briana L. Sobecks, Alexander S. Powers…·Merritt C. Maduke

The paper investigates how BIM1 selectively inhibits CLC-Ka over CLC-Kb by analyzing cryo-EM structures and showing that interactions with a conserved lysine and dynamic gating-loop behavior underlie this selectivity.

DOI 10.1073/pnas.2605886123

humancryo-EM

𝕏 PostBluesky

BiophysicsbioRxivPreprintAug 27, 2026

Structural basis for nutrient-activated channel opening in bacterial spore germination receptors

Joshua C. Cofsky, Fernando H. Ramírez‐Guadiana, Briana L. Sobecks…·Andrew C. Kruse

The paper reports cryo-EM structures of GerA, revealing how nutrient binding triggers channel opening through allosteric switches and subunit interactions.

DOI 10.64898/2026.08.27.747515

bacteria (other)cryo-EM

𝕏 PostBluesky

BiophysicsNature CommunicationsPeer-reviewedJan 8, 2026

Molecular mechanism of exchange coupling in CLC chloride/proton antiporters

Deniz Aydın, Chih-Ta Chien, Jürgen Kreiter…·Merritt C. Maduke

The paper provides a mechanistic model for the 2:1 Cl-/H+ exchange in CLC transporters using structural and computational methods.

DOI 10.1038/s41467-025-68098-1

bacteria (other)structural biology

𝕏 PostBluesky