SELECTION OF ANTI-NUCLEAR ANTIGEN (ANA) REACTIVE B CELLS IN SYSTEMIC LUPUS ERYTHEMATOSUS.
Yemil Atisha‐Fregoso, Wenzhao Meng, Aaron M. Rosenfeld, Fang Liu, Thomas MacCarthy, Scott M. Feltman, Cynthia B. Aranow, Meggan C. Mackay, Chloe Terestchenko, Moriah Dunn, Matthew D. Scharff, Eline T. Luning Prak, Betty Diamond
This study analyzes B cell receptor sequences in SLE patients to understand autoreactive B cell selection and differentiation, finding that ABCs are enriched in autoreactivity and may arise from naive B cells through an extrafollicular pathway.
bioRxiv · Jan 8, 2025 · PreprintImmunology