Meggan C. Mackay

Mechanistic insights into B-cell activation and autoreactivity regulation in active SLE and remission.

This study compares B-cell subsets in active SLE, remission, and healthy controls to identify immunological differences and potential therapeutic targets.

IFN-associated B cell hyperactivity is highly enriched in SLE patients harboring Sm/RNP antibodies

The paper identifies a subgroup of SLE patients with high plasmablast frequency and IFN signature, enriched in those with Sm/RNP antibodies, linking IFN to B cell hyperactivity and autoantibody production.

SELECTION OF ANTI-NUCLEAR ANTIGEN (ANA) REACTIVE B CELLS IN SYSTEMIC LUPUS ERYTHEMATOSUS.

This study analyzes B cell receptor sequences in SLE patients to understand autoreactive B cell selection and differentiation, finding that ABCs are enriched in autoreactivity and may arise from naive B cells through an extrafollicular pathway.