Thomas MacCarthy

ExTRaCT is a gene search pipeline that identifies APOBEC3 Z-domains in novel bat genomes with high accuracy and efficiency.

This study analyzes B cell receptor sequences in SLE patients to understand autoreactive B cell selection and differentiation, finding that ABCs are enriched in autoreactivity and may arise from naive B cells through an extrafollicular pathway.

The paper develops a mutation simulator to assess genome robustness under COSMIC mutational signatures, finding higher resilience in human and bat genomes to APOBEC-related mutations.

The paper analyzes APOBEC3-driven mutagenesis in monkeypox virus genomes, finding over-representation of TC hotspots and under-representation of GC hotspots, suggesting potential for future human APOBEC3-mediated evolution.