Kinetic proofreading as a mechanism for transcriptional specificity in living human cells
Jee Min Kim, David A. Ball, Thomas A Johnson, Chris DInzeo, Hyeon Jin Cho, Laurent L. Ozbun, Tatiana Karpova, Gianluca Pegoraro, Daniel R. Larson
This study shows that transcriptional specificity is achieved through kinetic proofreading, where promoters discriminate specific TF interactions based on dwell time rather than occupancy.
bioRxiv · Mar 18, 2026 · PreprintBiophysics