Author

Laurent L. Ozbun

National Institutes of HealthORCID 0000-0002-0862-3929Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Assay:imaging· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

Gianluca PegoraroiD· 2 shared Tatiana KarpovaiD· 2 shared Adib KeikhosraviiD· 1 shared Chris DInzeo· 1 shared Daniel R. LarsoniD· 1 shared David A. BalliD· 1 shared Faisal AlmansouriD· 1 shared Hyeon Jin ChoiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCell Biology

Gianluca PegoraroORCID

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2 papers

Recent·Most cited

Re-establishment of TAD boundary organization during DNA replication

Theodore Busby, Adib Keikhosravi, Mohamadreza Fazel, Faisal Almansour, Kathleen S Metz Reed, Laurent L. Ozbun, Tatiana Karpova, Gianluca Pegoraro, Tom Misteli

The paper identifies DNA replication machinery components as critical for TAD boundary re-establishment during DNA replication.

bioRxiv · Jul 9, 2026 · PreprintCell Biology

Kinetic proofreading as a mechanism for transcriptional specificity in living human cells

Jee Min Kim, David A. Ball, Thomas A Johnson, Chris DInzeo, Hyeon Jin Cho, Laurent L. Ozbun, Tatiana Karpova, Gianluca Pegoraro, Daniel R. Larson

This study shows that transcriptional specificity is achieved through kinetic proofreading, where promoters discriminate specific TF interactions based on dwell time rather than occupancy.

bioRxiv · Mar 18, 2026 · PreprintBiophysics