Jee Min Kim

Highly Constrained Kinetic Models for Single-Cell Gene Expression Analysis

This study introduces a kinetic model that integrates scRNA-seq and imaging data to simulate gene transcription dynamics and identifies conserved quantities and improved models for transcription factor mechanisms.

Kinetic proofreading as a mechanism for transcriptional specificity in living human cells

This study shows that transcriptional specificity is achieved through kinetic proofreading, where promoters discriminate specific TF interactions based on dwell time rather than occupancy.

FACT is recruited to the +1 nucleosome of transcribed genes and spreads in a Chd1-dependent manner

The paper identifies that FACT binds partially unwrapped nucleosomes in transcribed genes and spreads along genes in a Chd1-dependent manner.

Single-molecule imaging of chromatin remodelers reveals role of ATPase in promoting fast kinetics of target search and dissociation from chromatin

The paper uses single-molecule imaging to study chromatin remodelers in budding yeast, revealing their fast kinetics and ATP-dependent dissociation from chromatin.

Live-cell single particle imaging reveals the role of RNA polymerase II in histone H2A.Z eviction

The paper uses live-cell single particle imaging to show that RNA polymerase II and Kin28/Cdk7 kinase are required for H2A.Z eviction in yeast, linking it to transcription processes.

Unidirectional fork movement coupled with strand-specific histone incorporation ensures asymmetric histone inheritance

The paper shows that histone H4 is asymmetrically inherited in Drosophila male germline stem cells during asymmetric division, while H2A and H2B are symmetrically inherited.