Hyeon Jin Cho

Highly Constrained Kinetic Models for Single-Cell Gene Expression Analysis

This study introduces a kinetic model that integrates scRNA-seq and imaging data to simulate gene transcription dynamics and identifies conserved quantities and improved models for transcription factor mechanisms.

Kinetic proofreading as a mechanism for transcriptional specificity in living human cells

This study shows that transcriptional specificity is achieved through kinetic proofreading, where promoters discriminate specific TF interactions based on dwell time rather than occupancy.