Chrislaine Withers-Martinez

This study develops an in vitro system to study SERA6 maturation and validates inhibitors that block malaria parasite egress.

This study shows that PKG regulation in malaria parasites involves cGMP saturation and activation loop phosphorylation, with phosphorylation being essential for in vivo function.

This study functionally inactivates the Plasmodium falciparum plasmepsin V gene using CRISPR-Cas9 and DiCre recombination, showing it is essential for parasite viability in asexual blood stages.