Author

Christa Han

Johns Hopkins University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Andrew S PekosziD· 1 shared Heba H. MostafaiD· 1 shared Hisuan Liu· 1 shared Julie M. NortoniD· 1 shared Jyothsna GirishiD· 1 shared Katherine FenstermacheriD· 1 shared Madeline YunkeriD· 1 shared Nicholas J. SwansoniD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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1 shared paperMicrobiology

Andrew S PekoszORCID

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1 paper

Recent·Most cited

Clade-defining mutations in human H1N1 hemagglutinin protein from 2021-2023 have opposing effects on in vitro fitness and antigenic drift

Nicholas J. Swanson, Jyothsna Girish, Madeline Yunker, Hisuan Liu, Julie M. Norton, Christa Han, Heba H. Mostafa, Katherine Fenstermacher, Richard Eric Rothman, Andrew S Pekosz

This study identifies clade-defining mutations in H1N1 hemagglutinin that improve viral fitness but reduce neutralization by vaccine-induced antibodies, revealing an evolutionary trade-off between replication and immune evasion.

bioRxiv · May 18, 2024 · PreprintMicrobiology