Author

Richard Eric Rothman

Johns Hopkins UniversityORCID 0000-0002-1017-9505Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3 Approach:experimental assay· 2 Approach:statistical model· 2 Approach:benchmark study· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Andrew S PekosziD· 3 shared Katherine FenstermacheriD· 3 shared Anne P. WerneriD· 2 shared Elgin Henry AkiniD· 2 shared Heba H. MostafaiD· 2 shared Julie M. NortoniD· 2 shared Alexis GardunoiD· 1 shared Amary FalliD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersMicrobiology

Andrew S PekoszORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Emergence of an Antigenically Drifted and Reassorted Influenza B Virus at the end of the 2024-25 Influenza Season

Elgin Henry Akin, David A. Villafuerte, Anne P. Werner, Matthew Pinsley, Corinne Pierce, Amary Fall, Omar Riyadh Abdullah, Julie M. Norton, Richard Eric Rothman, Katherine Fenstermacher, Yu‐Nong Gong, Eili Y. Klein, Heba H. Mostafa, Andrew S Pekosz

This study identifies an antigenically drifted and reassorted Influenza B virus, C.3.1/re, emerging late in the 2024-25 season, which is poorly neutralized by existing vaccines and may impact future vaccine strain selection.

mBio · Jun 22, 2026Peer-reviewedMicrobiology

Low levels of H5N1 HA and NA antibodies in the human population are boosted by seasonal A/H1N1 infection but not by A/H3N2 infection or influenza vaccination

Anne P. Werner, Cosette G. Schneider, Elgin Henry Akin, Juliahna Hayes, Katherine Fenstermacher, Richard Eric Rothman, Lynda Coughlan, Andrew S Pekosz

The paper measures antibody responses to bovine A/H5N1 HA and NA in vaccinated and infected individuals, finding that A/H1N1 infection boosts neutralizing antibodies but vaccination and A/H3N2 infection do not.

mBio · Oct 31, 2025Peer-reviewedImmunology

International multi-cohort analysis identifies novel framework for quantifying immune dysregulation in critical illness: results of the SUBSPACE consortium

Andrew Reese Moore, Hong Zheng, Ananthakrishnan Ganesan, Yehudit Hasin-Brumshtein, Manoj V. Maddali, Joseph E. Levitt, Tom van der Poll, Jingyi Lu, Hjalmar R. Bouma, Brendon P. Scicluna, Evangelos J. Giamarellos‐Bourboulis, Antigone Kotsaki, Ignacio Martín‐Loeches, Alexis Garduno, Jeremiah S. Hinson, , Purvesh Khatri

The paper identifies a novel framework to quantify immune dysregulation in critical illness by analyzing transcriptomic data across multiple cohorts.

Nature Medicine · Sep 30, 2025Peer-reviewedImmunology

Clade-defining mutations in human H1N1 hemagglutinin protein from 2021-2023 have opposing effects on in vitro fitness and antigenic drift

Nicholas J. Swanson, Jyothsna Girish, Madeline Yunker, Hisuan Liu, Julie M. Norton, Christa Han, Heba H. Mostafa, Katherine Fenstermacher, Richard Eric Rothman, Andrew S Pekosz

This study identifies clade-defining mutations in H1N1 hemagglutinin that improve viral fitness but reduce neutralization by vaccine-induced antibodies, revealing an evolutionary trade-off between replication and immune evasion.

bioRxiv · May 18, 2024 · PreprintMicrobiology