Overcoming myeloid-driven resistance to CAR T therapy by targeting SPP1
Sharareh Gholamin, Heini M. Natri, Yuqi Zhao, Shengchao Xu, Maryam Aftabizadeh, Begonya Comin-Anduix, Supraja Saravanakumar, Christian Masia, Robyn A. Wong, Lance M. Peter, Mei-I Chung, Evan D. Mee, Brenda Aguilar, Renate Starr, Davis Yuri Torrejon, , Christine E. Brown
This study identifies SPP1+ macrophages as key drivers of resistance to CAR T therapy in solid tumors and shows that targeting SPP1 can overcome this resistance.
bioRxiv · Apr 1, 2025 · PreprintCancer Biology