Author

Christian Seca

University of Liège

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Alex von KriegsheimiD· 1 shared Anisa AlijuiD· 1 shared Arnaud BlommeiD· 1 shared Chinmayi PednekariD· 1 shared David P. SumptoniD· 1 shared Denis Heusdens· 1 shared Didier D CataldoiD· 1 shared Domien VannesteiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Alex von KriegsheimORCID

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1 paper

Recent·Most cited

mTORC2 stabilizes HIF-1β to coordinate metabolic adaptation in lung cancer

Morgane Paque, Ning An, Marine Leclercq, Anisa Aliju, Elodie Renaude, Domien Vanneste, Denis Heusdens, Jair Marques, Chinmayi Pednekar, Tillmann Bedau, Juan Fernández-García, Fabienne Perin, Raphael Vanleyssem, Christian Seca, Kim Eiden, , Arnaud Blomme

This study identifies mTORC2 as a convergent dependency in lung cancer that stabilizes HIF-1β to drive metabolic adaptation and tumor progression, revealing a therapeutic target in sphingolipid metabolism.

bioRxiv · Sep 3, 2026 · PreprintCancer Biology