Modeling of DNA methylation in cis reveals principles of chromatin folding in vivo in the absence of crosslinking and ligation
Josef Redolfi, Yinxiu Zhan, Christian Valdes, Mariya Kryzhanovska, Isabel Misteli Guerreiro, Vytautas Iešmantavičius, Guido Tiana, Tim Pollex, Jop Kind, Sébastien A. Smallwood, Wouter L. de Laat, Luca Giorgetti
The paper introduces damC, a method to measure chromatin structure in vivo without crosslinking or ligation, confirming TADs and CTCF loops and showing chromatin rigidity below 5 kilobases.
bioRxiv · Sep 3, 2018 · PreprintGenomics