Isabel Misteli Guerreiro

The paper shows that genome-lamina interactions are reconfigured during limb development to prime regulatory domains for gene activation and support cell-fate decisions.

This study identifies H3K27me3's role in regulating genome-nuclear lamina interactions and allelic asymmetry during early mouse embryogenesis through single-cell LAD profiling and chromatin state analysis.

This paper introduces EpiDamID, a method to profile histone modifications and transcriptomes at single-cell resolution, and demonstrates its application in mouse and zebrafish systems.

The paper compares Hoxd gene regulation in mammalian vibrissae and avian feather primordia with trunk elongation in mice and chickens, showing lineage-specific enhancer usage and functional divergence in conserved CREs.

The paper shows that chemically-defined conditions and signaling molecules can generate primitive endoderm-like cells and support post-implantation-like epiblast development in vitro.

The paper introduces damC, a method to measure chromatin structure in vivo without crosslinking or ligation, confirming TADs and CTCF loops and showing chromatin rigidity below 5 kilobases.