Tim Pollex

X-inactivation escapee domains are CTCF-cohesin independent chromatin compartments

The paper investigates the role of CTCF and cohesin in X-inactivation escapee domains and finds that these domains are self-sustaining chromatin compartments independent of CTCF and cohesin.

CTCF, BEAF-32 and CP190 are not required for the initial establishment of TADs in early Drosophila embryos, but have locus specific roles

The paper shows TADs form during zygotic genome activation in Drosophila embryos without CTCF, BEAF-32, or CP190, but these factors have locus-specific roles in boundary insulation.

New enhancer-promoter interactions are gained during tissue differentiation and reflect changes in E/P activity

The paper identifies new enhancer-promoter interactions gained during tissue differentiation in Drosophila embryos, showing that E/P proximity correlates with activation during terminal differentiation.

Modeling of DNA methylation in cis reveals principles of chromatin folding in vivo in the absence of crosslinking and ligation

The paper introduces damC, a method to measure chromatin structure in vivo without crosslinking or ligation, confirming TADs and CTCF loops and showing chromatin rigidity below 5 kilobases.