Yinxiu Zhan

MiTo is a framework for analyzing mitochondrial single-cell lineage tracing data, outperforming existing methods in pre-processing and clonal inference, and providing insights into cell lineage and gene regulatory network heritability.

The paper inverts a topological domain and shows it causes limited gene expression changes but affects inter-domain communication, particularly in Xist expression.

The paper quantifies how enhancer-promoter interactions influence transcription through nonlinear relationships and reveals mechanisms of transcriptional control via chromosome structure.

The paper uses live-cell imaging to show that chromosomal contacts within TADs are dynamic and stabilized by CTCF and cohesin.

deepBlink is a neural network method for automatically detecting and localizing diffraction-limited spots, outperforming existing methods on six datasets.

The paper uses single-molecule imaging to study mRNA localization in stress granules and processing bodies during the integrated stress response and finds similar translation and degradation rates for mRNA in these compartments compared to cytosol.

The paper introduces damC, a method to measure chromatin structure in vivo without crosslinking or ligation, confirming TADs and CTCF loops and showing chromatin rigidity below 5 kilobases.