Connectomics by Sequencing Reveals Self-Organizing Principles of Neuronal Networks in Cerebral Organoids
Ábel Vértesy, Ramsey Najm, Balint Doleschall, Sergey V. Isaev, Michael Zabolocki, Maria Novatchkova, Thomas Rainer Burkard, Christian Ziegler, Simone Krautberger, Chong V. Li, Igor I. Adameyko, Juergen A. Knoblich
The paper develops COSCO to map neuronal connectivity in cerebral organoids and shows self-organizing network motifs and disease-related topological changes.
bioRxiv · Oct 8, 2026 · PreprintNeuroscience