Thomas Rainer Burkard

Connectomics by Sequencing Reveals Self-Organizing Principles of Neuronal Networks in Cerebral Organoids

The paper develops COSCO to map neuronal connectivity in cerebral organoids and shows self-organizing network motifs and disease-related topological changes.

Kinetic logic of uridylation-mediated RNA decay

This study investigates how uridylation mediates RNA decay in Drosophila by showing how Tailor generates oligo(U) intermediates and how Dis3l2 decodes these to initiate decay.

Single-cell brain organoid screening identifies developmental defects in autism

The paper uses CRISPR and single-cell transcriptomics to screen ASD risk genes in brain organoids, identifying developmental defects and regulatory modules linked to autism.

Rapid nucleus-scale reorganization of chromatin in neurons enables transcriptional adaptation for memory consolidation

This study shows that chromatin reorganizes at the nucleus scale in neurons in response to stimuli, enabling rapid transcriptional changes for memory consolidation.

Dynamics of activating and repressive histone modifications in Drosophila neural stem cell lineages and brain tumors

The paper analyzes histone modifications in Drosophila neural stem cells and their progeny to understand lineage decisions and epigenetic regulation during CNS development.

The transcription factor Odd-paired regulates temporal identity in transit-amplifying neural progenitors via an incoherent feed-forward loop

The paper identifies odd-paired (opa) as a key regulator of temporal patterning in neural progenitors through an incoherent feedforward loop involving Osa and D.

Thiol-linked alkylation for the metabolic sequencing of RNA

SLAM-seq enables RNA polymerase II-dependent gene expression dynamics analysis by detecting 4-thiouridine incorporation at single-nucleotide resolution in mouse embryonic stem cells.