The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia
Ralda Nehme, Olli P. H. Pietiläinen, Mykyta Artomov, Matthew Tegtmeyer, Vera Valakh, Leevi Lehtonen, Christina Bell, Tarjinder Singh, Aditi Trehan, J. L. Sherwood, Danielle K. Manning, Emily R. Peirent, Rhea Malik, Ellen J. Guss, Derek Hawes, , Kevin C. Eggan
This study investigates how the 22q11.2 deletion affects gene expression in neural progenitor cells and neurons, linking it to schizophrenia risk through altered presynaptic gene products.
Nature Communications · Jun 27, 2022Peer-reviewedNeuroscience