Alexander A. Loboda

Multi-modal image analysis for large scale cancer tissue studies within IMMUcan

The paper presents two workflows for analyzing multiplexed imaging data from cancer tissues, applied to over 10,000 samples from 2500 patients, enabling large-scale tumor microenvironment studies.

CR1 variants contribute to FSGS susceptibility across multiple populations.

The paper identifies CR1 variants as a risk factor for FSGS across diverse populations through a case-control study and variant analysis.

Discordant calls across genotype discovery approaches elucidate variants with systematic errors

The paper identifies discordant genotype calls across sequencing methods in gnomAD, provides a blacklist of problematic variants, and introduces a classifier to detect such variants in other datasets.

GCDPipe: risk gene, cell type, and drug ranking for complex traits

GCDPipe ranks risk genes, cell types, and drugs for complex traits using GWAS and expression data, showing effectiveness in disease applications.

The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia

This study investigates how the 22q11.2 deletion affects gene expression in neural progenitor cells and neurons, linking it to schizophrenia risk through altered presynaptic gene products.

A platform for case-control matching enables association studies without genotype sharing

The paper develops a method to match control samples to case cohorts for genetic association studies without sharing genotypes, using singular value decomposition and provides an online library of controls.