Author

Aditi Trehan

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Alexis O. AparicioiD· 2 shared Kevin C. EgganiD· 2 shared Matthew TegtmeyeriD· 2 shared Michael Robert MurphyiD· 2 shared Olli P. H. PietiläineniD· 2 shared Peiguo ShiiD· 2 shared Ralda NehmeiD· 2 shared Samouil L. FarhiiD· 2 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersGenomics

Alexis O. AparicioORCID

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Author profile →

4 papers

Recent·Most cited

Decoding the MYC locus reveals a druggable ultraconserved RNA element

Peiguo Shi, Feiyue Yang, Tala FNU, Wesley Huang, Alexis O. Aparicio, Colin H. Kalicki, Aditi Trehan, Michael Robert Murphy, Esther R. Rotlevi, Linqing Xing, Muredach P. Reilly, Jianwen Que, Xuebing Wu

The paper maps the functional fitness landscape of the MYC locus, identifies an ultraconserved RNA element critical for MYC function, and shows it can be targeted to kill MYC-addicted cancer cells.

bioRxiv · Jan 30, 2026 · PreprintGenomics

Astrocytic cell adhesion genes linked to schizophrenia correlate with synaptic programs in neurons

Olli P. H. Pietiläinen, Aditi Trehan, Daniel Meyer, Jana M. Mitchell, Matthew Tegtmeyer, Vera Valakh, Hilena Gebre, Theresa Chen, Emilia Vartiainen, Samouil L. Farhi, Kevin C. Eggan, Steven A. McCarroll, Ralda Nehme

The paper shows that astrocyte-neuron interactions enhance synaptic gene expression in neurons and correlate with schizophrenia risk genes.

Cell Reports · Jan 1, 2023Peer-reviewedMolecular Biology

The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia

Ralda Nehme, Olli P. H. Pietiläinen, Mykyta Artomov, Matthew Tegtmeyer, Vera Valakh, Leevi Lehtonen, Christina Bell, Tarjinder Singh, Aditi Trehan, J. L. Sherwood, Danielle K. Manning, Emily R. Peirent, Rhea Malik, Ellen J. Guss, Derek Hawes, , Kevin C. Eggan

This study investigates how the 22q11.2 deletion affects gene expression in neural progenitor cells and neurons, linking it to schizophrenia risk through altered presynaptic gene products.

Nature Communications · Jun 27, 2022Peer-reviewedNeuroscience

RNA-guided cell targeting with CRISPR/RfxCas13d collateral activity in human cells

Peiguo Shi, Michael Robert Murphy, Alexis O. Aparicio, Jordan S. Kesner, Zhou Fang, Ziheng Chen, Aditi Trehan, Xuebing Wu

This paper demonstrates that targeting a single marker RNA with CRISPR/RfxCas13d causes collateral transcriptome destruction, enabling inhibition of cell proliferation or suppression of cell state transition in human cells.

bioRxiv · Nov 30, 2021 · PreprintMolecular Biology