Lysosomal multi-omics reveals altered sphingolipid catabolism as driver of lysosomal dysfunction in the aging brain.
Chinmoy Sarkar, Yi Chen, Dexter PH Nguyen, Mehari M Weldemariam, Yulemni Morel, Amir A. Mehrabani-Tabari, Nikki Gorny, Olivia Pettyjohn-Robin, Nivedita Hegdekar, Sagarina Thapa, Sazia Arefin Kachi, Sabrina Bustos, Stephanie Zalesak‐Kravec, Christina Williams, Nicholas Leahy, , Marta M. Lipinski
The paper uses multi-omics analysis of lysosomes to identify age-related sphingolipid catabolism changes linked to lysosomal dysfunction in the aging brain.
bioRxiv · Sep 10, 2025 · PreprintNeuroscience