Jace W. Jones

This study shows that isoflurane anesthesia and surgery worsen lipid dysregulation and neural dysfunction in APOE4 mice, leading to neurological impairments.

The paper uses multi-omics analysis of lysosomes to identify age-related sphingolipid catabolism changes linked to lysosomal dysfunction in the aging brain.

This study shows that inhibiting autophagy-lysosomal function worsens lipid metabolism reprogramming and dysfunction in microglia and monocytes after brain injury.

This study identifies lipid nanoparticles from maca that reduce inflammation and improve survival in sepsis models by sequestering pro-inflammatory cytokines and acute phase proteins.