Sagarina Thapa

This study shows that Rubicon promotes neuroinflammation and oxidative stress after traumatic brain injury by affecting autophagy and ROS production, and suggests it as a potential therapeutic target.

The paper uses multi-omics analysis of lysosomes to identify age-related sphingolipid catabolism changes linked to lysosomal dysfunction in the aging brain.

This study shows that inhibiting autophagy-lysosomal function worsens lipid metabolism reprogramming and dysfunction in microglia and monocytes after brain injury.