Evolutionary conserved reciprocal senescence and tumor suppressor signals limit lifetime cancer
Liqiong Liu, Stephani A. Davis, Shamila Yusuff, Ann Strange, Yonghua Zhuang, Prasanna Kumar Vaddi, Kathleen Flaherty, Kelly Jara, Joseph Kramer, Christine Archer, Schuyler Lee, Bifeng Gao, Adrie van Bokhoven, Wei Wang, Sharon R. Pine, , Hatem E. Sabaawy
This study identifies an evolutionary conserved INK4-homolog, ink4ab, which triggers senescence and suppresses cancer by regulating reciprocal senescence and apoptosis pathways.
bioRxiv · Dec 28, 2024 · PreprintCancer Biology