Author

Hatem E. Sabaawy

University of Colorado AnschutzORCID 0000-0002-7976-303XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Sharon R. PineiD· 2 shared Adrie van BokhoveniD· 1 shared Ann StrangeiD· 1 shared Bifeng GaoiD· 1 shared Christene A. HuangiD· 1 shared Christine Archer· 1 shared D. Ross CamidgeiD· 1 shared Danielle Mintzlaff· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

Sharon R. PineORCID

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2 papers

Recent·Most cited

Bivalent CD47 Immunotoxin for Targeted Therapy of Lung Cancer

Jihong Ma, Dinoop Ravindran Menon, Zhaohui Wang, Danielle Mintzlaff, Hugh Rock, Lauren E. Giesy, Christene A. Huang, David W. Mathes, Trevor Nydam, Elizabeth Anne Pomfret, D. Ross Camidge, Hatem E. Sabaawy, Sharon R. Pine, Zhirui Wang

This study develops a bivalent CD47 immunotoxin for NSCLC therapy, showing strong preclinical efficacy in multiple mouse models.

Biomedicines · Sep 26, 2026Peer-reviewedCancer Biology

Evolutionary conserved reciprocal senescence and tumor suppressor signals limit lifetime cancer

Liqiong Liu, Stephani A. Davis, Shamila Yusuff, Ann Strange, Yonghua Zhuang, Prasanna Kumar Vaddi, Kathleen Flaherty, Kelly Jara, Joseph Kramer, Christine Archer, Schuyler Lee, Bifeng Gao, Adrie van Bokhoven, Wei Wang, Sharon R. Pine, , Hatem E. Sabaawy

This study identifies an evolutionary conserved INK4-homolog, ink4ab, which triggers senescence and suppresses cancer by regulating reciprocal senescence and apoptosis pathways.

bioRxiv · Dec 28, 2024 · PreprintCancer Biology